Enclear Therapies is developing device-based systems to halt the progression of neurodegenerative diseases by removing toxic proteins known to drive pathology. The system 1. continuously recirculates cerebrospinal fluids (CSF) and 2. targets and removes toxic proteins from CSF.
Clearance of Toxic Proteins from the CSF
ALS & FTD (C9orf72)
Toxic proteins are generated in ALS and FTD patients with C9orf72 mutations. These proteins travel through the brain and spinal fluids and are taken up by neurons of the motor system that are very sensitive to their toxicity which leads to degeneration of these neurons leading to paralysis. EnClear has developed a proprietary technology which clears these toxic proteins from the brain and spinal fluids of C9orf72 ALS and FTD patients. We are now developing this technology into a device that will recirculate the brain and spinal fluids while the toxic proteins are rendered harmless. With this technology Enclear aims to stop or significantly slow down the neuronal degeneration in ALS and FTD patients with C9orf72 mutations. This technology can potentially be used for other forms of ALS and FTD in which toxic prion like proteins propagate through the brain and spinal fluids.